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Aptar STELMI logo

map 22 Avenue of Nations,
95944 ROISSY CDG Cedex - France

phone 33 + (0) 1 48 63 56 56
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Your partner worldwide, specialized in manufacturing high components elastomer range for injectable products.

About us
Guided by the quality, service and innovation for over 50 years and privileged partner of the largest pharmaceutical companies, Aptar Stelmi specializes in the development and production of components

Whether caps for bottles or components for prefilled syringes for new or existing applications, our teams of experts work closely with customers to build quality solutions in compliance with the the strictest requirements.


Our strengths
Quality Solutions
We offer elastomer components that meet the most stringent pharmaceutical requirements. Our manufacturing processes, GMP, are at the forefront of technology: automation, vision systems by camera, cleanrooms ISO 5 ... These methods including sterilization steps are guaranteed by our quality system and procedures - a high quality environment for your drugs.

global leader and preferred partner
Our organization and our offer is structured to facilitate the implementation of strategies and meet your needs with the objective of adding value sustainably. This strategy has enabled us to become a leader in this very demanding market.
Quality, innovation and customer service are our strengths recognized around the world and form the cornerstone of the special partnership we have built with our clients.

innovative partner
Pioneering products and cleaner processes that have now become industry standards, our technical and scientific experts teams design products and processes in our future International Centre Technique


  • pistons
  • Shin Needles
  • Tip Caps
  • Components for Cartridge



  • parenterals high volume (LVP)
  • parenteral preparations in small volume (SVP)
  • lyophilization
  • Diagnostic



  • Ready to be sterilized
  • Sterile
  • aseptic systems transferred
  • PremiumCoat ™


PremiumCoat™ The alternative stoppers coated for sensitive drugs.
Fragile injectable drugs with very high value added, a dynamic market

The biotech drugs include many complex and sensitive molecules produced artificially through organic agents grown in living systems such as microorganisms, plants or animal cells, they represent a major therapeutic advance.
The biotechnology market is 20% of the world pharmaceutical market with an average annual growth of 10% between 2010 and 2015 or 2 times a growth higher than the global drug market.

sensitive injectable drugs require high-end components

The biotech drugs are unstable and fragile in nature. Also, it is extremely important to maintain the integrity of the closure and minimize the interaction container / content. The use of a conventional elastomeric stopper may not be the optimal solution for these fragile drugs.

PremiumCoat launched early 2015 is a new range of elastomeric stoppers developed by Aptar Stelmi from a premium formulation, pure and approved.
The surface of the elastomer is coated with a thin film ETFE during manufacture of the cap. This film acts as an effective barrier against most of extractables and leachables compounds that could be released from the elastomer. And the compatibility of the medication with the cap is significantly enhanced by PremiumCoat.
Our first design the 20 mm was launched in February 2015 2016 and February, we completed the range with 13 mm coated.


Around the world, technical experts and technical-regulatory closer to our customers

As a true partner, you can count on us: we provide comprehensive technical and regulatory services throughout the lifecycle of your product, that is to say, from development through validation, industrialization , regulatory registrations and post-launch tracking.

We can provide full documentation so you can make the right choice for premium products: specifications, information sheets, technical studies, technical and regulatory information, validation records and technical bulletins.
Our engineers are working internally and with you to meet your needs processes, product improvement, development of customized products to help you get started on the drug market safely and quickly.



    logo 3cfrance

      mapIndustrial Zone, 18380, CHAPEL OF ANGILLON
      phone33 + (0) 2 48 81 66 66
      emailSerge KRONENBERG
      search www.3c-france.com


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    such 00 41 32 420 76 40

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     mapChemin de l'Orme, 69280 Marcy L'Etoile - France
      phone33 + (0) 4 78 87 20 00
      email Ronan LE ROCH

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    map302 - 304 street Garibaldi, 69007 LYON, France
    phone0894 675 685
    emailAntoine BABIN

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    address153 Wharf Rancy, 94380 Bonneuil sur Marne- LA FRANCE
    such 00 33 1 43 78 73 76

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      map158 Avenue Roger Salengro, 69100 VILLEURBANNE
      phone33 + (0) 4 78 93 34 35
      emailFrederic Cheviron
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    addressBlaufelder Strasse 45, 74564 CRAILSHEIM - GERMANY
    such + 49 7951 402-0

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    address BP 21 - Rue Giessen - TRIEMBACH AU VAL - France

    such 33 + (0) 3 88 58 91 18

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    address 103 Rue Charles Michels,
          93206Saint Denis - FRANCE
    such 00 33 1 49 22 45 55



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    map10 street Balls, 63200 RIOM, France
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    emailGildas LAVENANT

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    map1 reu Bodiniere, 37230 Fondettes, France
    phone 33 + (0) 2 47 42 48 48
    emailStephanie BURGER-PRIN
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    address16 Héierchen Street, L-4940 Bascharage

    such 00 35 2 26 33 73 1

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        map 25 avenue des Arts, 69100 Villeurbanne
        phone 33 + (0) 4 72 44 49 00
        emailSaban KAPLAN & Stéphane BRAT
        search http://metrologie.cetiat.fr/

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    charles river logo emd

    address 9 Allée Moulin Berger,
    69130 Ecully - FRANCE
    such 00 800 15 78 97 43

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    Cleanroom Management International

    address LA FRANCE
    such +33 2 54 95 70 95
    address BELGIUM
     such+32 2 531 11 21
    CMI preferred partner for your controls:
    Validation of clean rooms, equipment qualification, calibration laboratory and on-site

     logo CONFARMA

    address ZI Rue du Canal d'Alsace,
    68490 Hombourg - FRANCE
    such 00 33 3 89 83 37 20
  • Darron


    map35 Avenue Geneva74000 Annecy, France
    phone 33 + (0) 4 50 69 59 91
    email info@darron.fr
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      mapGeneral Patton Street, 2984 Contern, Luxembourg
      phone+352 3666 5210
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      search www.tyvek.fr


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    such 00 33 825 888 001

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    phone 00 33 4 67 22 40 95
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     such 33 + (0) 3 44 31 05 38

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      phone33 + (0) 4 76 98 31 82
      emailAnaïs Vercin


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    such 33 + (0) 1 69 10 88 88

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      phone33 + (0) 3 80 52 32 05
      emailBenoit PERSIN
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    such 00 33 1 41 39 98 00

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      phone33 + (0) 1 69 31 76 80
      emailPhilippe Gausset
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    General activity of the Group

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      mapDombes park Class A Activities, 176 Route Balan
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      phone33 + (0) 4 78 06 35 08
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      search www.ionisos.com


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    addressStreet 20 of Industry,
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    such +41 32 374 34 11

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    emailAndreas Schweizer
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     such + 1 (434) 293-3081

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    such +33 8732 1611

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    such 00 33 825 045 645

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    address30 bd de Douaumont, 75017 Paris - FRANCE
    such 00 33 1 47 37 06 00

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    ne industry

    Brimrose logo

    map2 instead of Touraine, 78000 Versailles - France
    phone33 + (0) 6 87 93 52 83
    search http://www.nir-industry.com/

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    H4R 2E9,Saint-Laurent (Montreal) - CANADA

    such 00 1 514 668 2835

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       such 33 + (0) 3 20 63 06 48

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    oxopharma 2

    map40 Georges Pompidou avenue,
    69003 Lyon, France
    phone33 + (0) 4 78 95 03 56
    emailPhilippe GUYARD
    search www.oxo-group.com

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    mapRue Marcel Paul 917, 94500 Champigny / Marne, France
    phone33 + (0) 1 48 82 58 29
    emailChristian JOUBERT

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    map13 avenue du Hoggar
    91969 Courtaboeuf Cedex, France
    phone33 + (0) 1 60 92 31 70
    emailRégis DILHAN
    search www.oxygen-web.com

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    address3 street Gaudines BP90234, 78102 St Germain en Laye Cedex

    such 00 33 1 30 61 32 29


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    map210 / 136 of Carver Road,
    40170 Saint Julien en Born, France
    phone33 + (0) 6 25 33 20 41

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    map30 rue Jean Rostand, 91893 Orsay, France
    phone33 + (0) 1 60 10 32 96
    emailBernard BILLAT
    search http://www.pmeasuring.com/fr

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    Pharmadec 2015 cartridge

    map 3, rue Copernic, 41260 La Chaussee St Victor - FRANCE
    phone33 + (0)2 54 74 99 02 / 33 + (0) 6 71 00 34 43
    emailMarie-Françoise TAYEB:in / mf.tayeb@groupeidec.com 

    search http://www.pharmadec.com

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    logo pharmadis

    map 19 Street Ticks, 63118 CEBAZAT - France
    phone 33 + (0) 4 73 25 26 10
    emailMarc LOUIS

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     Fabre OPHRDC stone

    map3 BC. Hubert Curien, BP13562, 31035 Cedex1 Toulouse, FRANCE
    phone + 33 (0)5 34 50 66 00
    emailChristopher & COMPANIONemailAlexander BASTIT
    search www.pierre-fabre.com/cdmo

    The manufacturing injectable products is a major focus of the offer OPHRDC Pierre Fabre.
    Since 1991 on its plant in Pau, Pierre Fabre manufactures injectable way for the world market (EU - USA - Japan-Brazil ....), using aseptic processing or terminal sterilization.

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  • PX'Therapeutics

    px therapeutics

    map7 parvis Louis Néel - CS 20050,
    38040 Grenoble, France
    phone33 + (0) 4 38 02 36 50
    emailDelphine BOULANGER
    search www.px-therapeutics.com

    PX'Therapeutics is a French Contract Development and Manufacturing Organization Offering services dedicated to the development and biomanufacturing of recombinant proteins, monoclonal antibodies Including.

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  • Rapid Micro Biosystems, Inc.

    logo rapidmicrobiosystems

    map1001 Pawtucket Blvd West, Suite 280,
    01854 Lowell, MA, FUnited States
    phone+ 1 978-349-3200
    emailSylvie KNEES

    Rapid Micro Biosystems Delivers the Growth Direct ™ System, an automated, non-destructive detection and enumeration rapid technology based on the Compendial method for microbial quality control in pharmaceutical manufacturing.

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  • Repligen

    Repligen logo

    mapSeyon Street 41, 02453 Waltham - United States
    phone 00 33 781 250 0111
    search http://www.repligen.com

    Inspiring advances in bioprocessing, Repligen is a trusted partner in upstream and downstream process intensification pre-packed disposable chromatography.

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  • rommelag AG

     logo rommelag

    map Fabrikweg 16, 5033 Buchs - SWITZERLAND
    phone + 41 62 834 55 55
    email tanja.frey@rommelag.ch

    World leader manufacturers and suppliers of machinery "Blow-Fill-Seal" for the sterile packaging of pharmaceutical liquids and creams for cosmetics.

    The bottelpack® aseptic machines ensure the manufacture of flexible containers, the filling and saddling in a single operation; guaranteeing optimum protection of the sterile product.

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  • Sartorius Stedim FRANCE

    Sartorius Stedim Biotech 

    addressZI Les Paluds Avenue Jouques CS71058,
    13781 Aubagne Cedex - FRANCE

    such 00 33 4 42 84 56 00

    Sartorius Stedim Biotech is a leading international provider of products and services to the biopharmaceutical industry, for the development and manufacture of pharmaceuticals safely and efficiently.

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  • schülke France

    Schuelke logo

    map22 Terrace Bellini, 92806 Puteaux, France
    phone33 + (0) 1 42 91 42 42
    emailIsabelle VALADE
    search www.schuelke.fr

    For over 125 years, hygiene is the heartSchülke activity.

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    address4 rue du Commandant d'Estienne d'Orves, 92390Villeneuve-la-Garenne - FRANCE
    such 33 + (0) 1 41 06 95 91

    SGS Life Science Services, a member of the SGS Group, the world's leading inspection, verification, analysis and certification for many industries, is particularly specialized in the field of clinical trials phase I-IV (PCBs ) and analytical development (GLP / GMP) including, bioanalysis, viral safety, cell characterization and quality control for raw materials, developing products and finished products of chemical or biological natures.

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    addressBinningerstrasse 116, 4123 Allschwil - SWITZERLAND
    such 00 41 614 854 444

    Founded in 1968, SKAN is now one of the pioneers in the fields of activity such as machinery and equipment for the field of ultra-cleanliness and containment, study and manufacturing insulators for chemical and pharmaceutical industries. 

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    SOPAC logo

    map142 / 176 BC. Stalingrad
    92712 Colombes Cedex - France
    phone 33 + (0) 1 47 99 61 00

    SOPAC, created in 1958, is a French company specialized in the distribution and calibration of measuring instruments for the validation of thermal processes, control of the cold chain (storage and transport), mapping devices, control of hygiene and microbial detection.

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     address Murtenstrasse 116 - 18 POBox
    3202 Frauenkappelen - SWITZERLAND

    such 00 41 31 750 50 10

    Our range of services includes all stages of an investment project, the planning process up to industrial scale.

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    spectrumlabs logo

     addressHoeksteen 13, 4815 PR, BREDA
     such 33 + (0) 6 80 99 41 58

    SPECTRUMLABS.com is a global leader in membrane separations technologies for the pharmaceutical, diagnostic and biotechnology. KrosFlo® mark process SPECTRUMLABS filtration products comprise filters disposable hollow fiber used in microfiltration applications flow, ultrafiltration and tangential infusion.

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    addressParc Saint Christophe - Pole Edison 3,95861Cergy Pontoise - FRANCE
    such 00 33 1 34 22 53 99

    Subsidiary of SPIE, SPIE Services Life Sciencesoffers expert services specifically designed for pharmaceutical and cosmetic industries.

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    address2 rue André Citroen, 95130Franconville - FRANCE
    such + 33 1 34 44 23 23

    STERIGENE is an engineering company of
    clean and sterile processes in which differentactivities still consist, after listening toits customers to design, develop and qualifyintegrated solutions in process equipment,Technical services and consumables roomsown.

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     STERIS logo ast

      map Moray Road, Elgin Industrial Estate, Swindon SN2 8XS, United Kingdom
      phone +420 603 425 156
      emailKatie PAY
      search www.steris-ast.com

    STERIS Applied Sterilization Technologies (AST STERIS) Operates as a global beg of sterilization, specialist applications and contamination control solutions supplier providing our Customers with a network of over 50 contract sterilization and laboratory facilities worldwide.

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     STERIS Life Sciences

     address8 Abbot Street Rastignac
    45380 La Chapelle Saint Mesmin - FRANCE
     such 33 + (0) 2 38 84 85 40

    STERIS is a global leader in infection prevention, contamination control, surgical and intensive care technologies, and more.

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  • SWAN


    addressZa Bièvre Dauphine - 57 rue du Grand Champ
    38140 Apprieu - FRANCE

    such 00 33 4 76 06 56 90

    For compendiales waters SWAN offers its TOC meter (total organic carbon measurement) with a system of reliable measurement, simple and inexpensive: a differential conductivity measurement after a carbon mineralization produced by the energy of UV. This device is certified to meet the requirements IQ, PQ, OQ.
    (Installation Qualification, Qualification Procedure,qualification process).

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    c logo system bioprocess industry

    mapZI Wood Lot - Alley Chamille,
    26130 Saint Paul Trois Chateaux, France
    phone33 + (0) 4 75 54 86 00
    emailSébastien Aubaret
    search www.system-c-industrie.com

    Our company offers screening systemsaverage flow rate, fermenters and the cytoculteursmicrovolume to several thousand liters dedicatedthe fermentation or cell culture.

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    mapThe 12 Defense 92973 Paris La Défense, France
    phone33 + (0) 1 47 78 54 06
    emailCécile JOLIBOIS
    search www.technip.com

    Engineering services from concept to completion and qualification of pharmaceutical production in project management and turnkey services.

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  • TECH

    Tech Talk logo

      mapWoodstock Park, Cedar 3, 97 Driveway Alexandre Borodine,
    69800 Saint Priest
      phone 33 + (0) 4 78 67 35 40
      emailDenis LEBRE
      search www.technipharm.fr


    Engineering clean and sterile processes.

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    logo telstar

    map5, Manouchian group of street, La France
    phone 33 + (0) 1 30 13 18 70
    emailEric LHOMMEAU
    search http://www.telstar-lifesciences.com


     logo thermo fisher scientific

    address6 road Paisy, 69570 Dardilly - FRANCE
    such 33 + (0) 4 72 52 33 70

    Microbiology division of Thermo Fisher Scientific develops and manufactures culture media and microbiological diagnostic tests for quality control in the pharmaceutical industry.

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    logo tsi

      mapTechnological hotel BP 100, Technopole of Château-Gombert
    13382 Marseille, France
      phone33 + (0) 1 41 19 21 99
      emailCommercial contact
      search www.tsi.com


    International leader in measurement technology for over 50 years, TSI Incorporated (www.tsi.com) designs and manufactures precision instruments used for contamination control, respirators fit testing, exposure monitoring, indoor air quality, ventilation testing, aerosol research instruments, and other key parameters in the environment.

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  • Validapro EUROPE

    logo Validapro

    map240 rue Jean Bart Agora 4, 31670 Labege, France
    phone33 + (0) 5 61 00 13 13
    emailSophie MICHEL
    search http://validapro.com/

    Validapro is a services company for the pharmaceutical, biotechnology and medical device.


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     vai logo pantone200

      mapLee Boulevard 15, 19355 Malvern - Pennsylvania, USA
      phone 610-644-8335
      emailMoira O'MALLEY
      search www.sterile.com

    VAI's manufacturing and testing operations mirror current GMP and GLP standards.
    We offer a comprehensive line of disinfectants, sporicidal, residue removers, detergents / cleaners and quality process water.

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     addressBIA Top Mishawaka, 3 BC Concorde,
    91325 Wissous - FRANCE
     url http://www.veoliawatersti.com

     such 33 + (0) 1 69 75 25 75

    Veolia WATER TECHNOLOGIES hasComplete control of pharmaceuticals in the water cycle, biotech & cosmetics : Production, distribution of purified water (PW) And water for injection (WFI). Its standard equipment or custom cover needs ranging from 100 l / h to over 30 m3 / h and meet regulations.

    Recommendations in force: USP, FDA, GAMP and cGMP to ensure performance,
    reliability and security.
    Veolia WATER TECHNOLOGIES customers can also rely on its national network of services for rapid response maintenance or supply of consumables / spare parts.

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    address Avenue de la Gare 15, 1870 CH-Monthey - SWITZERLAND
    such + 41 78 946 12 42

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